Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 8/20 | 0.36 |
| ▸ | KDM5A | P29375 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.34 |
| ▸ | PTPN12 | Q05209 | 2/20 | 0.34 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BRS3 | P32247 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205928 | 0.89 | NAMPT (0.39) | GAASMN1; SMN2NAMPTHDAC1HTT | |
| SCHEMBL8209847 | 0.83 | FNTA (0.41) | ALDH1A1 | |
| SCHEMBL8213603 | 0.82 | HTR2B (0.40) | GAASMN1; SMN2NAMPTKDM4EHTR2B | |
| SCHEMBL7861749 | 0.82 | HDAC1 (0.41) | GAASMN1; SMN2NAMPTKDM5AKDM4C | |
| SCHEMBL8205834 | 0.81 | GAA (0.42) | GAASMN1; SMN2NAMPTHDAC1HTT | |
| SCHEMBL8205732 | 0.81 | FNTA (0.37) | GAASMN1; SMN2NAMPTHTTALDH1A1 | |
| SCHEMBL8206086 | 0.79 | GAA (0.43) | GAASMN1; SMN2NAMPTKDM4CHTT | |
| SCHEMBL7703282 | 0.76 | TBXAS1 (0.43) | — | |
| SCHEMBL7703466 | 0.76 | TBXAS1 (0.43) | — | |
| SCHEMBL7703278 | 0.76 | TBXAS1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054865-A1 | FARNESYL TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041235-A1 | FARNESYL TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |