Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 12/20 | 0.66 |
| ▸ | CA1 | P00915 | 7/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CA4 | P22748 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Toluenesulfonamide SCHEMBL7862511 | 1.00 | CA2 (0.66) | CA2CA1ALDH1A1TSHRCA9 | |
| Methanesulfonamide SCHEMBL6777577 | 0.84 | CTSS (0.60) | CA2CA1ALDH1A1TSHRPPARG | |
| Methanesulfonamide SCHEMBL6898028 | 0.84 | CTSS (0.60) | CA2CA1ALDH1A1TSHRPPARG | |
| SCHEMBL7874195 | 0.82 | CTSS (0.57) | CA2CA1ALDH1A1TSHRCA9 | |
| SCHEMBL7874192 | 0.82 | CTSS (0.57) | CA2CA1ALDH1A1TSHRCA9 | |
| SCHEMBL352156 | 0.81 | CTSS (0.68) | CA2ALDH1A1TSHRPPARGPPARA | |
| SCHEMBL478905 | 0.81 | CTSS (0.68) | CA2ALDH1A1TSHRPPARGPPARA | |
| SCHEMBL1486229 | 0.81 | CTSS (0.68) | CA2ALDH1A1TSHRPPARGPPARA | |
| SCHEMBL4395744 | 0.81 | CTSS (0.68) | CA2ALDH1A1TSHRPPARGPPARA | |
| SCHEMBL7862513 | 0.80 | CA2 (0.52) | CA2ALDH1A1TSHRPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310095-B1 | INHIBITING OR TREATING CANCER, TREATING INTIMAL HYPERPLASIA ASSOCIATED WITH RESTENOSIS AND ATHEROSCLEROSIS, INHIBITING POST-TRANSLATIONAL MODIFICATION OF ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE AND/OR GERANYLGERANYLTRANSFERASE | UNIVERSITY OF PITTSBURGH | 2001-10-30 | — | — | US | disclosed |