Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 7/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018098 | 0.92 | CXCR1 (0.44) | CXCR1CXCR2ALDH1A1RAB9AGABRA5 | |
| SCHEMBL9017990 | 0.90 | GABRA5 (0.43) | CXCR1CXCR2RAB9AGABRA5SMN1; SMN2 | |
| SCHEMBL9018094 | 0.88 | CXCR1 (0.43) | CXCR1CXCR2GABRA5EPHX2 | |
| SCHEMBL9018431 | 0.87 | CXCR2 (0.47) | CXCR1CXCR2ALDH1A1RAB9AGABRA5 | |
| SCHEMBL9137956 | 0.85 | P4HTM (0.43) | CXCR1CXCR2ALDH1A1RAB9APOLB | |
| SCHEMBL8869725 | 0.82 | P4HTM (0.39) | CXCR1CXCR2ALDH1A1RAB9APOLB | |
| SCHEMBL7862789 | 0.82 | GABRA5 (0.45) | CXCR1CXCR2ALDH1A1RAB9AGABRA5 | |
| SCHEMBL9018441 | 0.82 | GABRA5 (0.52) | GABRA5CYP2C9CYP2C19 | |
| SCHEMBL9018289 | 0.82 | P4HTM (0.46) | CXCR1CXCR2RAB9AGABRA5SMN1; SMN2 | |
| SCHEMBL9018172 | 0.82 | MMP8 (0.47) | ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |