Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 6/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018316 | 0.92 | CXCR1 (0.45) | CXCR1CXCR2ALDH1A1RAB9AEPHX2 | |
| SCHEMBL9018431 | 0.91 | CXCR2 (0.47) | CXCR1CXCR2ALDH1A1RAB9AHTR7 | |
| SCHEMBL9018289 | 0.89 | P4HTM (0.46) | CXCR1CXCR2RAB9AEPHX2GABRA5 | |
| SCHEMBL9018418 | 0.87 | CXCR2 (0.46) | CXCR1CXCR2HTR7EPHX2GABRA5 | |
| SCHEMBL7862789 | 0.87 | GABRA5 (0.45) | CXCR1CXCR2ALDH1A1RAB9AHTR7 | |
| SCHEMBL7871752 | 0.84 | CXCR1 (0.39) | CXCR1CXCR2ALDH1A1RAB9AEPHX2 | |
| SCHEMBL7874627 | 0.84 | GABRA5 (0.43) | CXCR1CXCR2ALDH1A1RAB9AEPHX2 | |
| SCHEMBL9143213 | 0.83 | MAPK1 (0.48) | CXCR1CXCR2ALDH1A1RAB9A | |
| SCHEMBL9017990 | 0.82 | GABRA5 (0.43) | CXCR1CXCR2RAB9AGABRA5SMN1; SMN2 | |
| SCHEMBL9018493 | 0.81 | MMP8 (0.49) | ALDH1A1RAB9AGABRA5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |