Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869429 | 0.92 | ALDH1A1 (0.47) | ALDH1A1HSD17B10HPGDEGFRPOLB | |
| SCHEMBL7867679 | 0.91 | ALDH1A1 (0.40) | ALDH1A1MAPTHPGDCA1CA2 | |
| SCHEMBL7867696 | 0.91 | LMNA (0.42) | ALDH1A1MAPTEGFRPOLBMEN1 | |
| SCHEMBL7862714 | 0.90 | ALDH1A1 (0.45) | ALDH1A1HSD17B10HPGDEGFRPOLB | |
| SCHEMBL7862663 | 0.89 | POLB (0.45) | ALDH1A1MAPTHSD17B10EGFRPOLB | |
| SCHEMBL7869400 | 0.88 | CA12 (0.42) | ALDH1A1MAPTEGFRMEN1KMT2A | |
| SCHEMBL9018243 | 0.88 | ALDH1A1 (0.50) | ALDH1A1HSD17B10HPGDEGFRPOLB | |
| SCHEMBL9574715 | 0.88 | CA2 (0.49) | MAPTEGFRMEN1KMT2ACA1 | |
| SCHEMBL8868111 | 0.87 | ALDH1A1 (0.51) | ALDH1A1MAPTHSD17B10HPGDEGFR | |
| SCHEMBL7874632 | 0.87 | ALDH1A1 (0.56) | ALDH1A1MAPTPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |