Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GRK2 | P25098 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7870511 | 0.94 | ALDH1A1 (0.56) | ALDH1A1KMT2AMEN1CA1CA2 | |
| SCHEMBL7871641 | 0.93 | CA1 (0.56) | ALDH1A1KMT2AMEN1CA1CA2 | |
| SCHEMBL7867669 | 0.90 | TSHR (0.57) | ALDH1A1KMT2AMEN1CA1CA2 | |
| SCHEMBL7862836 | 0.87 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1CA1CA2 | |
| SCHEMBL7870454 | 0.87 | ALDH1A1 (0.51) | ALDH1A1KMT2ACA1CA2CA7 | |
| SCHEMBL7862780 | 0.86 | CA1 (0.56) | ALDH1A1KMT2AMEN1CA1CA2 | |
| SCHEMBL9517098 | 0.86 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1CA1CA2 | |
| SCHEMBL7867696 | 0.85 | LMNA (0.42) | ALDH1A1KMT2AMEN1CA1CA2 | |
| SCHEMBL7867837 | 0.84 | NLRP3 (0.51) | ALDH1A1KMT2AMEN1MAPTTSHR | |
| SCHEMBL8869792 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KMT2AMEN1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |