Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868363 | 0.90 | ALOX15 (0.54) | ALOX15HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL27393640 | 0.85 | ALOX15 (0.39) | ALOX15MAPTALDH1A1KDM4EGAA | |
| SCHEMBL7868426 | 0.85 | HPGD (0.50) | ALOX15HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL7874904 | 0.85 | MAPT (0.45) | ALOX15HPGDMAPTALDH1A1CYP2C19 | |
| SCHEMBL7871217 | 0.80 | ALOX15 (0.51) | ALOX15HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL7868379 | 0.76 | ALOX15 (0.50) | ALOX15HPGDALDH1A1KDM4ECYP2C19 | |
| SCHEMBL7868349 | 0.74 | MAPT (0.46) | ALOX15HPGDMAPTCYP2C19CYP1A2 | |
| SCHEMBL1189663 | 0.72 | ABL1 (0.68) | ALOX15HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL31366555 | 0.71 | MAPT (0.61) | ALOX15MAPTALDH1A1LMNAGAA | |
| SCHEMBL1041696 | 0.71 | MAPT (0.61) | ALOX15MAPTALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313290-B1 | Azolobenzazepine derivatives and compositions and method of use thereof | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| US-6124281-A | TREATING STROKES | ZENECA LIMITED (GB) | 2000-09-26 | — | — | US | disclosed |
| EP-0888350-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032883-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |