Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863165 | 0.85 | ALOX15 (0.49) | HPGDALOX15ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL27371670 | 0.85 | MAP2K4 (0.41) | HPGDALOX15ALDH1A1KDM4ELMNA | |
| SCHEMBL7863072 | 0.85 | HPGDS (0.44) | HPGDALOX15HPGDSALDH1A1CYP1A2 | |
| SCHEMBL7868363 | 0.84 | ALOX15 (0.54) | HPGDALOX15ALDH1A1KDM4ECDC25B | |
| SCHEMBL7871217 | 0.81 | ALOX15 (0.51) | HPGDALOX15ALDH1A1XBP1KDM4E | |
| SCHEMBL1753182 | 0.77 | HPGDS (0.60) | HPGDHPGDSALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7868379 | 0.75 | ALOX15 (0.50) | HPGDALOX15ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL1969117 | 0.73 | HPGDS (0.59) | HPGDHPGDSALDH1A1KDM4EHSD17B10 | |
| SCHEMBL27321802 | 0.73 | RAB9A (0.63) | HPGDHPGDSALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL1189663 | 0.72 | ABL1 (0.68) | HPGDALOX15ALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313290-B1 | Azolobenzazepine derivatives and compositions and method of use thereof | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| US-6124281-A | TREATING STROKES | ZENECA LIMITED (GB) | 2000-09-26 | — | — | US | disclosed |
| EP-0888350-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032883-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |