Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869910 | 0.92 | KCNMA1 (0.46) | KCNMA1MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL7863107 | 0.85 | ALOX15 (0.47) | ALDH1A1HTTHPGDALOX15ALPL | |
| SCHEMBL27452003 | 0.83 | ALDH1A1 (0.49) | KCNMA1MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL7868379 | 0.81 | ALOX15 (0.50) | ALDH1A1KMT2AMEN1PKMHTT | |
| SCHEMBL267821 | 0.79 | MAPT (0.65) | MAPTALDH1A1KMT2AMEN1PKM | |
| SCHEMBL7871914 | 0.79 | MAPT (0.40) | KCNMA1MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL27371673 | 0.74 | HPGD (0.44) | KCNMA1ALDH1A1SMN1; SMN2HTTHPGD | |
| SCHEMBL7868349 | 0.74 | MAPT (0.46) | KCNMA1MAPTKMT2AMEN1MAPK1 | |
| SCHEMBL5508703 | 0.74 | POLB (0.46) | MAPTALDH1A1KMT2AMEN1PKM | |
| SCHEMBL8119629 | 0.72 | MAPT (0.45) | MAPTALDH1A1KMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313290-B1 | Azolobenzazepine derivatives and compositions and method of use thereof | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| US-6124281-A | TREATING STROKES | ZENECA LIMITED (GB) | 2000-09-26 | — | — | US | disclosed |
| EP-0888350-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032883-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |