Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7863170 | 0.92 | KCNMA1 (0.46) | KCNMA1HPGDALOX15MAPTL3MBTL1 | |
| SCHEMBL27371673 | 0.83 | HPGD (0.44) | KCNMA1HPGDALDH1A1SMN1; SMN2HTT | |
| SCHEMBL7868379 | 0.83 | ALOX15 (0.50) | HPGDALOX15ALDH1A1MEN1KMT2A | |
| SCHEMBL7868349 | 0.82 | MAPT (0.46) | KCNMA1HPGDALOX15MAPTL3MBTL1 | |
| SCHEMBL7863107 | 0.81 | ALOX15 (0.47) | HPGDALOX15ALDH1A1HTTALPL | |
| SCHEMBL7871914 | 0.79 | MAPT (0.40) | KCNMA1HPGDMAPTL3MBTL1LMNA | |
| SCHEMBL7874904 | 0.78 | MAPT (0.45) | KCNMA1HPGDALOX15MAPTL3MBTL1 | |
| SCHEMBL7863171 | 0.77 | HPGD (0.43) | KCNMA1HPGDALOX15MAPTL3MBTL1 | |
| SCHEMBL7863072 | 0.77 | HPGDS (0.44) | KCNMA1HPGDALOX15MAPTL3MBTL1 | |
| SCHEMBL27452003 | 0.74 | ALDH1A1 (0.49) | KCNMA1MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313290-B1 | Azolobenzazepine derivatives and compositions and method of use thereof | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| US-6124281-A | TREATING STROKES | ZENECA LIMITED (GB) | 2000-09-26 | — | — | US | disclosed |
| EP-0888350-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032883-A1 | AZOLOBENZAZEPINE DERIVATIVES AS NEUROLOGICALLY ACTIVE AGENTS | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |