Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
| ▸ | TNKS | O95271 | 1/20 | 0.30 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29773667 | 0.87 | RXRA (0.33) | KIF11 | |
| Hydrochloric Acid SCHEMBL3685419 | 0.81 | CHRNB2 (0.35) | BRD4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7863570 | 0.79 | BRD4 (0.34) | KIF11BRD4CREBBPNPC1LMNA | |
| Hydrochloric Acid SCHEMBL7189365 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL7194135 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL7192637 | 0.79 | — | — | |
| SCHEMBL25224711 | 0.78 | BRD4 (0.34) | KIF11BRD4CREBBPNPC1LMNA | |
| SCHEMBL28041264 | 0.78 | BRD4 (0.34) | KIF11BRD4CREBBPNPC1LMNA | |
| Fluoride Ion SCHEMBL5183953 | 0.78 | CHRNB2 (0.35) | BRD4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7198752 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074557-A2 | Transition metal complexes, ligands, catalysts, and their use in the polymerisation of olefins | TARGOR GmbH (DE) | 2001-02-07 | — | — | EP | disclosed |