Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.30 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoride Ion SCHEMBL5183953 | 0.96 | CHRNB2 (0.35) | CHRNB2CHRNA4ALDH1A1HSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL7863578 | 0.81 | KIF11 (0.35) | ALDH1A1BRD4 | |
| Hydrochloric Acid SCHEMBL4089006 | 0.79 | CHRNB2 (0.35) | CHRNB2CHRNA4ALDH1A1HSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL4088340 | 0.79 | CHRNB2 (0.35) | CHRNB2CHRNA4ALDH1A1HSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL7807228 | 0.78 | ALDH1A1 (0.35) | ALDH1A1HSD17B10HPGDMAPK1 | |
| Hydrochloric Acid SCHEMBL27488712 | 0.77 | CHRNB2 (0.34) | CHRNB2CHRNA4ALDH1A1HSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL8426993 | 0.77 | CHRNB2 (0.34) | CHRNB2CHRNA4ALDH1A1HSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL29773667 | 0.77 | RXRA (0.33) | — | |
| SCHEMBL6930673 | 0.76 | CHRNB2 (0.36) | CHRNB2CHRNA4ALDH1A1HSD17B10HPGD | |
| SCHEMBL5860378 | 0.76 | CHRNB2 (0.36) | CHRNB2CHRNA4ALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113302211-A | Process for preparing catalyst for polymerizing olefins | 韩华思路信株式会社 | 2021-08-24 | — | — | CN | claimed |
| CN-110770265-A | Catalyst system and method of use thereof | 埃克森美孚化学专利公司 | 2020-02-07 | — | — | CN | claimed |
| US-20160333174-A1 | Blend for Use in Automobile Application | TOTAL RES & TECHNOLOGY FELUY (BE) | 2016-11-17 | — | — | US | claimed |
| EP-1737893-A1 | PHOSPHORUS BRIDGED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION | ExxonMobil Chemical Patents Inc. (US) | 2007-01-03 | — | — | EP | claimed |
| WO-2005108435-A1 | PHOSPHORUS BRIDGED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2005-11-17 | — | — | WO | claimed |
| EP-0856525-A1 | Selective activity of metallocene-type catalyst for isotactic poly-alpha-olefin production | FINA TECHNOLOGY, INC. (US) | 1998-08-05 | — | — | EP | claimed |
| CN-113302211-A | Process for preparing catalyst for polymerizing olefins | 韩华思路信株式会社 | 2021-08-24 | — | — | CN | disclosed |
| CN-108137748-B | Process for preparing polyolefins having one or more pendant functional groups | SABIC环球技术有限责任公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-108368270-B | Process for preparing a polyolefin-based graft copolymer comprising a first functionalized short chain branched polyolefin block and one or more polymer side chains | SABIC环球技术有限责任公司 | 2021-03-02 | — | — | CN | disclosed |
| CN-108291032-B | Process for preparing a polyolefin graft copolymer comprising a first long-chain branched polyolefin block and one or more polymer side chains | SABIC环球技术有限责任公司 | 2021-01-26 | — | — | CN | disclosed |
| CN-107223138-B | Process for preparing polyolefins having one or more end-functionalized branches | SABIC环球技术有限责任公司 | 2020-10-23 | — | — | CN | disclosed |
| CN-107531829-B | Process for preparing a block copolymer comprising a first polyolefin block and a second polymer block and product obtained from said process | SABIC环球技术有限责任公司 | 2020-09-22 | — | — | CN | disclosed |
| CN-107207712-B | Process for preparing a graft copolymer comprising a polyolefin backbone and one or more polymeric side chains and product obtained from said process | SABIC环球技术有限责任公司 | 2020-08-07 | — | — | CN | disclosed |
| CN-1217685-A | VULCANIZED MOLDING HAVING SURFACE DECORATIVE LAYER, PAINTED THERMOPLASTIC RESIN COMPOSITION AND PAINTED ELASTOMER COMPOSITION | MITSUI CHEMICALS INC (JP) | 1999-05-26 | — | — | CN | disclosed |
| CN-1216055-A | RUBBER COMPOSITIONS FOR TIRES | MITSUI CHEMICALS INC (JP) | 1999-05-05 | — | — | CN | disclosed |
| CN-1216053-A | SHRINKABLE FILM MADE FROM OLEFINE COPOLYMER | MITSUI CHEMICALS INC (JP) | 1999-05-05 | — | — | CN | disclosed |
| CN-1209827-A | 'alpha'-olefin/aromatic vinyl copolymer composition and products thereof | MITSUI CHEMICALS INC (JP) | 1999-03-03 | — | — | CN | disclosed |
| EP-0856525-A1 | Selective activity of metallocene-type catalyst for isotactic poly-alpha-olefin production | FINA TECHNOLOGY, INC. (US) | 1998-08-05 | — | — | EP | disclosed |
| CN-1160055-A | Process for reducing by-product in product mixture | HOECHST AG (DE) | 1997-09-24 | — | — | CN | disclosed |
| CN-1137527-A | Metallocene compound and its use as catalyst component | HOECHST AG (DE) | 1996-12-11 | — | — | CN | disclosed |