Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 5/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.42 |
| ▸ | GCGR | P47871 | 4/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | MATK | P42679 | 1/20 | 0.42 |
| ▸ | FRK | P42685 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7777792 | 0.74 | GYS1 (0.54) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL3939765 | 0.71 | MAPK14 (0.45) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL4183686 | 0.71 | PTGS1 (0.43) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL11285169 | 0.69 | KMT2A (0.73) | MAPK11MAPK14ALPLMEN1KMT2A | |
| SCHEMBL7773094 | 0.68 | PTGS1 (0.49) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL11168349 | 0.68 | ALPL (0.46) | MAPK11MAPK14ALPLMEN1KMT2A | |
| SCHEMBL6440359 | 0.67 | ALDH1A1 (0.41) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL20074684 | 0.66 | ALDH1A1 (0.45) | ALPLMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7527869 | 0.66 | PTGS2 (0.46) | ALOX5PTGS2PTGS1 | |
| SCHEMBL2374242 | 0.66 | ALDH1A1 (0.45) | MAPK13MAPK12MAPK11MAPK14GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6307047-B1 | PYRIDAZINONE COMPOUNDS; INHIBITORS OF CYCLOOXYGENASE-2 (COX-2); SELECTIVITY OF THESE COMPOUNDS FOR COX-2 MINIMIZES THE UNWANTED GI AND RENAL SIDE-EFFECTS SEEN WITH CURRENTLY MARKETED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS | ABBOTT LABORATORIES | 2001-10-23 | — | — | US | disclosed |