Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7866912 | 0.83 | SMN1; SMN2 (0.41) | GAAPFKFB3HDAC2HDAC8HDAC6 | |
| SCHEMBL7863291 | 0.81 | ITGB3 (0.45) | HTR6POLBPFKFB3HDAC2HDAC8 | |
| SCHEMBL7862046 | 0.81 | ITGB3 (0.45) | HTR6POLBPFKFB3ITGB3ITGAV | |
| SCHEMBL7861775 | 0.81 | EEF2K (0.43) | GAAHTR6POLBPFKFB3HDAC2 | |
| SCHEMBL7864234 | 0.81 | PGR (0.41) | HTR6POLBPFKFB3ITGB3ITGAV | |
| SCHEMBL7856530 | 0.81 | CA1 (0.54) | HTR6POLBPFKFB3HDAC2HDAC8 | |
| SCHEMBL7864756 | 0.80 | CA1 (0.38) | GAAHTR6PFKFB3HDAC2HDAC8 | |
| SCHEMBL7863261 | 0.79 | ITGB3 (0.43) | HTR6POLBPFKFB3ITGB3ITGAV | |
| SCHEMBL7863268 | 0.79 | ITGB3 (0.43) | HTR6POLBPFKFB3ITGB3ITGAV | |
| SCHEMBL7864664 | 0.78 | GBA1 (0.39) | GAAHTR6PFKFB3ITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | disclosed |