Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867774 | 0.83 | HSP90AA1 (0.39) | FLT4KDR | |
| SCHEMBL7872820 | 0.80 | HDAC1 (0.48) | PTGS2FLT4KDR | |
| SCHEMBL8412821 | 0.80 | — | — | |
| SCHEMBL7867928 | 0.74 | PTGS2 (0.41) | PTGS2FLT4KDRNPC1RAB9A | |
| SCHEMBL7872974 | 0.74 | HDAC1 (0.47) | FLT4KDR | |
| SCHEMBL17617642 | 0.73 | FGFR1 (0.41) | — | |
| SCHEMBL19770643 | 0.72 | TP53 (0.36) | — | |
| SCHEMBL18665248 | 0.70 | POLB (0.38) | — | |
| SCHEMBL17617641 | 0.69 | TLR9 (0.35) | — | |
| SCHEMBL7872739 | 0.69 | KIF11 (0.36) | PTGS2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316595-B1 | PNA synthesis using a base-labile amino protecting group | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-11-13 | — | — | US | disclosed |
| US-6121418-A | PNA synthesis using a base-labile amino protecting group | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-09-19 | — | — | US | disclosed |
| EP-0672701-B1 | PNA-synthesis using a base labile aminoprotecting group | HOECHST AG (DE) | 1999-07-28 | — | — | EP | disclosed |
| EP-0672701-A1 | PNA-synthesis using a base labile aminoprotecting group | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-20 | — | — | EP | disclosed |