Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTR1F | P30939 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868005 | 0.93 | HTR6 (0.41) | HTR6SLC6A4HTR1AKDM4ELMNA | |
| SCHEMBL7867413 | 0.81 | KDM4E (0.39) | HTR6KDM4ELMNAALOX15PARP1 | |
| SCHEMBL7866250 | 0.79 | KDM4E (0.41) | HTR6KDM4ELMNAALOX15MAPT | |
| SCHEMBL7865108 | 0.75 | HRH3 (0.45) | SLC6A4HTR1AL3MBTL1 | |
| Oxalic Acid SCHEMBL7867306 | 0.74 | SLC6A4 (0.66) | HTR6SLC6A4HTR1AKDM4ELMNA | |
| Oxalic Acid SCHEMBL7868026 | 0.74 | CYP19A1 (0.44) | HTR6SLC6A4PARP1ALKHTR1F | |
| Oxalic Acid SCHEMBL7867999 | 0.72 | DRD2 (0.41) | HTR6SLC6A4KDM4ELMNAALOX15 | |
| Oxalic Acid SCHEMBL7865005 | 0.71 | KDM4E (0.59) | HTR6SLC6A4HTR1AKDM4ELMNA | |
| SCHEMBL7859767 | 0.71 | HTR6 (0.42) | HTR6HTR1AKDM4ELMNAALOX15 | |
| SCHEMBL7867440 | 0.69 | HRH3 (0.45) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |