Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8596028 | 0.88 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL7773790 | 0.83 | PTGS2 (0.42) | PTGS2PTGS1SCN9A | |
| SCHEMBL215180 | 0.78 | PTGS2 (0.54) | PTGS2PTGS1 | |
| Benzenesulfonamide SCHEMBL7049598 | 0.75 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL8093805 | 0.70 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL7872129 | 0.69 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL8098107 | 0.69 | PTGS2 (0.52) | PTGS2PTGS1 | |
| SCHEMBL8095222 | 0.68 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL7860657 | 0.67 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL8346344 | 0.67 | PTGS2 (0.55) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140181-A1 | COMBINATION THERAPY OF RADIATION AND A COX-2 INHIBITOR FOR THE TREATMENT OF NEOPLASIA | G.D. SEARLE & CO. (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000038716-A1 | COMBINATION THERAPY OF RADIATION AND A COX-2 INHIBITOR FOR THE TREATMENT OF NEOPLASIA | G.D. SEARLE & CO. (US) | 2000-07-06 | — | — | WO | claimed |
| EP-0979077-A1 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE PREVENTION OF CARDIOVASCULAR DISORDERS | G.D. Searle & Co. (US) | 2000-02-16 | — | — | EP | disclosed |
| WO-1998047509-A1 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE PREVENTION OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1998-10-29 | — | — | WO | disclosed |