Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | GRK2 | P25098 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24129793 | 0.84 | CA2 (0.47) | HTTNPSR1KDM4EALDH1A1KMT2A | |
| SCHEMBL23049594 | 0.81 | MMP2 (0.59) | ALDH1A1CA2HSD11B1 | |
| SCHEMBL7704838 | 0.81 | ALDH1A1 (0.67) | HTTNPSR1KDM4EALDH1A1KMT2A | |
| SCHEMBL16144557 | 0.81 | KMT2A (0.57) | HTTNPSR1ALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL28149984 | 0.81 | HTT (0.57) | HTTNPSR1KDM4EALDH1A1KMT2A | |
| SCHEMBL7868867 | 0.80 | ALDH1A1 (0.65) | HTTNPSR1KDM4EALDH1A1KMT2A | |
| SCHEMBL7870815 | 0.79 | HTT (0.64) | HTTNPSR1KDM4EALDH1A1KMT2A | |
| SCHEMBL3650831 | 0.79 | CA2 (0.60) | ALDH1A1KMT2AMEN1CA2CA1 | |
| SCHEMBL12103715 | 0.79 | HTT (0.59) | HTTNPSR1KDM4EALDH1A1KMT2A | |
| SCHEMBL1001018 | 0.79 | HSD11B1 (0.69) | HTTNPSR1KDM4EALDH1A1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994104-A1 | ARYL (SULFIDE, SULFOXIDE AND SULFONE) DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-04-19 | — | — | EP | claimed |
| US-6300514-B1 | INHIBITING MATRIX METALLOPROTEINASES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | disclosed |
| EP-0994104-A1 | ARYL (SULFIDE, SULFOXIDE AND SULFONE) DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-04-19 | — | — | EP | disclosed |