Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 8/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 7/20 | 0.52 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TARS1 | P26639 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7871609 | 0.92 | P4HTM (0.55) | MCL1BCL2L1P4HTMEGFR | |
| SCHEMBL7871544 | 0.92 | MCL1 (0.49) | MCL1BCL2L1P4HTMOPRM1OPRD1 | |
| SCHEMBL7867912 | 0.88 | EGFR (0.47) | P4HTMEGFR | |
| SCHEMBL7862839 | 0.87 | SMN1; SMN2 (0.48) | P4HTMMMP2 | |
| SCHEMBL7871663 | 0.87 | EPHX2 (0.49) | P4HTMOPRM1OPRD1OPRK1 | |
| SCHEMBL9574735 | 0.87 | ALDH1A1 (0.52) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7870523 | 0.86 | MEN1 (0.47) | MCL1BCL2L1P4HTMOPRM1OPRD1 | |
| SCHEMBL7870440 | 0.86 | PTPN1 (0.49) | MCL1BCL2L1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9574724 | 0.86 | PGR (0.50) | MCL1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7874583 | 0.85 | NPC1 (0.45) | P4HTMOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |