Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869457 | 0.91 | P4HTM (0.47) | SMN1; SMN2LMNAMAPK1TDP1P4HTM | |
| SCHEMBL7871609 | 0.91 | P4HTM (0.55) | MAPK1TDP1P4HTMNAMPT | |
| SCHEMBL7862740 | 0.90 | ALDH1A1 (0.48) | SMN1; SMN2BDKRB1P4HTMPKMHSD17B10 | |
| SCHEMBL7869467 | 0.90 | MEN1 (0.48) | BDKRB1LMNAP4HTMPKMPPARA | |
| SCHEMBL9574752 | 0.89 | L3MBTL1 (0.53) | BDKRB1LMNAP4HTMPKMNAMPT | |
| SCHEMBL9574735 | 0.89 | ALDH1A1 (0.52) | SMN1; SMN2LMNAPKMALDH1A1 | |
| SCHEMBL7867912 | 0.89 | EGFR (0.47) | SMN1; SMN2P4HTMALDH1A1KDM4E | |
| SCHEMBL7870523 | 0.88 | MEN1 (0.47) | SMN1; SMN2LMNAP4HTMPPARAALDH1A1 | |
| SCHEMBL7869445 | 0.88 | PKM (0.43) | BDKRB1P4HTMPKMNAMPTALDH1A1 | |
| SCHEMBL7862672 | 0.87 | L3MBTL1 (0.47) | SMN1; SMN2BDKRB1LMNAMAPK1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |