Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 7/20 | 0.65 |
| ▸ | DPP4 | P27487 | 3/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL197990 | 1.00 | HDAC2 (0.65) | HDAC2DPP4AKR1C3AKR1C1CYP1A2 | |
| SCHEMBL5201978 | 1.00 | HDAC2 (0.65) | HDAC2DPP4AKR1C3AKR1C1CYP1A2 | |
| SCHEMBL124005 | 1.00 | HDAC2 (0.65) | HDAC2DPP4AKR1C3AKR1C1CYP1A2 | |
| SCHEMBL20011747 | 1.00 | HDAC2 (0.65) | HDAC2DPP4AKR1C3AKR1C1CYP1A2 | |
| SCHEMBL199332 | 1.00 | HDAC2 (0.65) | HDAC2DPP4AKR1C3AKR1C1CYP1A2 | |
| SCHEMBL25396765 | 1.00 | HDAC2 (0.65) | HDAC2DPP4AKR1C3AKR1C1CYP1A2 | |
| SCHEMBL8512122 | 1.00 | HDAC2 (0.65) | HDAC2DPP4AKR1C3AKR1C1CYP1A2 | |
| SCHEMBL197989 | 1.00 | HDAC2 (0.65) | HDAC2DPP4AKR1C3AKR1C1CYP1A2 | |
| Hydrochloric Acid SCHEMBL18094024 | 0.98 | HDAC2 (0.63) | HDAC2DPP4AKR1C3AKR1C1CYP1A2 | |
| Hydrochloric Acid SCHEMBL10461198 | 0.98 | HDAC2 (0.63) | HDAC2DPP4AKR1C3AKR1C1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3087094-B1 | BETA-HAIRPIN PEPTIDOMIMETICS AS SELECTIVE ELASTASE INHIBITORS | POLYPHOR AG (CH) | 2022-06-01 | — | — | EP | disclosed |
| US-10301260-B2 | Pyrrolidine GPR40 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-05-28 | — | — | US | disclosed |
| US-20170081282-A1 | PYRROLIDINE GPR40 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2017-03-23 | — | — | US | disclosed |
| US-9284352-B2 | Beta-hairpin peptidomimetics having CXCR4 antagonizing activity | POLYPHOR AG (CH) | 2016-03-15 | — | — | US | disclosed |
| US-8895499-B2 | β-hairpin peptidomimetics | POLYPHOR AG (CH) | 2014-11-25 | — | — | US | disclosed |
| US-8865656-B2 | Beta-hairpin peptidomimetics having CXCR4 antagonizing activity | POLYPHOR AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-8716242-B2 | β-hairpin peptidomimetics | POLYPHOR AG (CH) | 2014-05-06 | — | — | US | disclosed |
| US-20130189363-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | Universität Zürich (CH) | 2013-07-25 | — | — | US | disclosed |
| US-20120283196-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2012-11-08 | — | — | US | disclosed |
| US-20120135942-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2012-05-31 | — | — | US | disclosed |
| CN-102344399-A | Stereomers of (2S,4S)-4-phenylpyrrolidine-2-carboxylic acid and preparation method for salt thereof | WUHAN QIRUI PHARMACEUTICALS CO LTD | 2012-02-08 | — | — | CN | disclosed |
| US-6329502-B1 | VIRICIDES AGAINST HUMAN IMMUNODEFICIENCY VIRUS; TREATMENT OF AIDS (ACQUIRED IMMUNE DEFICIENCY SYNDROME) | JAPAN ENERGY CORPORATION (JP) | 2001-12-11 | — | — | US | disclosed |
| US-6313094-B1 | COMPOSITION FOR INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | JAPAN ENERGY CORPORATION (JP) | 2001-11-06 | — | — | US | disclosed |
| EP-0490667-B1 | HIV protease inhibitors | JAPAN ENERGY CORP (JP) | 1999-06-09 | — | — | EP | disclosed |
| EP-0490667-A2 | HIV protease inhibitors | JAPAN ENERGY CORPORATION (JP) | 1992-06-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135942-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | CXCR4, CXCL12, CXCR6 | HDAC2 4384/4885DPP4 685/4885AKR1C3 3537/4885 |
| US-20170081282-A1 | PYRROLIDINE GPR40 MODULATORS | GPR55, GPR65, GPR4 | HDAC2 2730/4885DPP4 1321/4885AKR1C3 1963/4885 |
| US-10301260-B2 | Pyrrolidine GPR40 modulators | GPR55, GPR65, GPR4 | HDAC2 2730/4885DPP4 1321/4885AKR1C3 1963/4885 |
| US-20120283196-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | CXCL12, CXCR4, CXCR1 | HDAC2 4516/4885DPP4 768/4885AKR1C3 3688/4885 |
| US-20130189363-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | CUTA, COL14A1, PEPD | HDAC2 4323/4885DPP4 376/4885AKR1C3 4451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.