Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7880092 | 0.84 | EPAS1 (0.40) | EPAS1MAPTPOLBMEN1KMT2A | |
| SCHEMBL7880088 | 0.79 | SMN1; SMN2 (0.38) | MAPTBCHECNR2POLBMEN1 | |
| SCHEMBL7740445 | 0.74 | MEN1 (0.39) | EPAS1MAPTBCHECNR2MEN1 | |
| SCHEMBL19717777 | 0.71 | POLB (0.49) | MAPTPOLBHPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL27782491 | 0.69 | IDO1 (0.50) | MAPTMEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL3101339 | 0.69 | TSHR (0.51) | MAPTTHRBMEN1KMT2AHPGD | |
| SCHEMBL7878669 | 0.68 | POLB (0.41) | POLBHPGDSMN1; SMN2LMNAKDM4A | |
| SCHEMBL30868193 | 0.68 | PDGFRB (0.46) | MAPTBCHECNR2MEN1KMT2A | |
| SCHEMBL7740423 | 0.67 | ALDH1A1 (0.37) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL2858710 | 0.66 | ALOX5 (0.47) | MAPTPOLBMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | disclosed |