Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | PARL | Q9H300 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28811993 | 0.81 | KDM4E (0.40) | ALDH1A1MAPTGLAHPGDACHE | |
| SCHEMBL7872853 | 0.79 | MAPT (0.39) | ALDH1A1MAPTGLAHPGDACHE | |
| Acridine SCHEMBL9348926 | 0.77 | ALDH1A1 (0.56) | ALDH1A1MAPTGLAHPGDACHE | |
| SCHEMBL9296399 | 0.76 | HTR3A (0.43) | ALDH1A1MAPTGLAHPGDACHE | |
| SCHEMBL57128 | 0.76 | PARL (0.38) | GLAPARLMGLLKMT2AALOX12 | |
| SCHEMBL3143334 | 0.76 | KDM4E (0.44) | ALDH1A1MAPTGLAHPGDPARL | |
| Diphenylether SCHEMBL1205239 | 0.76 | ALDH1A1 (0.46) | ALDH1A1PARLMGLLKMT2AALOX12 | |
| SCHEMBL2585788 | 0.75 | KDM4E (0.54) | ALDH1A1MAPTMGAMKMT2AKDM4E | |
| SCHEMBL9551382 | 0.74 | MGAM (0.54) | MGAMKDM4ENPC1RAB9ATOP2A | |
| Bicarbonate SCHEMBL28277654 | 0.74 | MGLL (0.36) | PARLMGLLKMT2AALOX12ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316595-B1 | PNA synthesis using a base-labile amino protecting group | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-11-13 | — | — | US | disclosed |
| US-6121418-A | PNA synthesis using a base-labile amino protecting group | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-09-19 | — | — | US | disclosed |
| US-6046306-A | SOLID PHASE SYNTHESIS OF PEPTIDE NUCLEIC ACIDS ALLOWING OLIGOMER TO BE CLEAVED OFF FROM THE SOLID SUPPORT UNDER THE ALKALINE CONDITIONS CONVENTIONALLY USED FOR OLIGONUCLEOTIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-04-04 | — | — | US | disclosed |
| EP-0672701-B1 | PNA-synthesis using a base labile aminoprotecting group | HOECHST AG (DE) | 1999-07-28 | — | — | EP | disclosed |
| EP-0672700-B1 | PNA-synthesis using an aminoprotecting group which is labile against weak acids | HOECHST AG (DE) | 1999-06-02 | — | — | EP | disclosed |
| EP-0672701-A1 | PNA-synthesis using a base labile aminoprotecting group | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0672700-A1 | PNA-synthesis using an aminoprotecting group which is labile against weak acids | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-20 | — | — | EP | disclosed |