Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30634705 | 0.97 | TSHR (0.53) | TSHRACHEALDH1A1CA1CA2 | |
| Fluoride Ion SCHEMBL943596 | 0.94 | TSHR (0.50) | TSHRACHEALDH1A1CA1CA2 | |
| Hydrochloric Acid SCHEMBL11444635 | 0.94 | TSHR (0.50) | TSHRACHEALDH1A1CA1CA2 | |
| Water SCHEMBL4384424 | 0.94 | TSHR (0.50) | TSHRACHEALDH1A1CA1CA2 | |
| SCHEMBL7874669 | 0.92 | TSHR (0.47) | TSHRACHEALDH1A1CA1CA2 | |
| Bromide SCHEMBL7886102 | 0.85 | TSHR (0.41) | TSHRACHEALDH1A1CA1CA2 | |
| SCHEMBL7874600 | 0.85 | ACHE (0.41) | TSHRACHEALDH1A1CA1CA2 | |
| Phenol SCHEMBL7872892 | 0.83 | TSHR (0.39) | TSHRACHEALDH1A1CA1CA2 | |
| Acetic Acid SCHEMBL1033265 | 0.81 | ALDH1A1 (0.41) | TSHRACHEALDH1A1CA1TDP1 | |
| Bromide SCHEMBL9067697 | 0.80 | TSHR (0.47) | TSHRACHEALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316575-B1 | MELT TRANSESTERIFICATION OF DIOL COMPOUND AND CARBOANTE COMPOUND USING CATALYST COMPRISING A PHOSPHORUS-CONTAINING BASIC COMPOUND QUATERNARY PHOSPHONIUM SALT TO FORM POLYCARBONATE | IDEMITSU KOSAN CO., LTD. (JP) | 2001-11-13 | — | — | US | claimed |
| US-5837425-A | PRESENSITIZATION OF PLATES, SUPPORTS, MULTILAYER, EXPOSURE TO ACTINIC RADIATION OF FILMS, DEVELOPMENT OF PLATES WITH ALKALI | FUJI PHOTO FILM CO., LTD. (JP) | 1998-11-17 | — | — | US | disclosed |
| EP-0716347-A1 | Developer for photosensitive lithographic printing plate | FUJI PHOTO FILM CO., LTD. (JP) | 1996-06-12 | — | — | EP | disclosed |
| EP-0516372-B1 | Concentrated dampening water composition for lithographic printing | FUJI PHOTO FILM CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5221330-A | Hydrophilic film-forming polymer, buffer, water miscible organic solvent, micelle-forming compound, water | FUJI PHOTO FILM CO., LTD. (JP) | 1993-06-22 | — | — | US | disclosed |
| EP-0516372-A1 | Concentrated dampening water composition for lithographic printing | FUJI PHOTO FILM CO., LTD. (JP) | 1992-12-02 | — | — | EP | disclosed |