Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ESR1 | P03372 | 4/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 2/20 | 0.32 |
| ▸ | CES1 | P23141 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3117767 | 0.89 | TDP1 (0.52) | TDP1CYP3A4ESR1ESR2GAA | |
| 1,2-Dibromoethane SCHEMBL28837174 | 0.87 | TDP1 (0.71) | TDP1CYP3A4ESR1ESR2GAA | |
| SCHEMBL3367511 | 0.85 | TDP1 (0.48) | TDP1CYP3A4ESR1ESR2GAA | |
| Dibromomethane SCHEMBL5329477 | 0.84 | TDP1 (0.75) | TDP1CYP3A4ESR1ESR2GAA | |
| Dibromomethane SCHEMBL7950072 | 0.84 | TDP1 (0.75) | TDP1CYP3A4ESR1ESR2GAA | |
| SCHEMBL319391 | 0.82 | TDP1 (0.63) | TDP1CYP3A4ESR1ESR2GAA | |
| SCHEMBL5453551 | 0.82 | TDP1 (0.63) | TDP1CYP3A4ESR1ESR2GAA | |
| Ethylene Glycol SCHEMBL25311579 | 0.81 | TDP1 (0.48) | TDP1CYP3A4ESR1ESR2GAA | |
| Propanol SCHEMBL16974060 | 0.80 | TDP1 (0.60) | TDP1CYP3A4ESR1ESR2GAA | |
| N-Propyl Bromide SCHEMBL1400032 | 0.80 | TDP1 (0.60) | TDP1CYP3A4ESR1ESR2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7173002-A | — | — | None | — | — | JP | disclosed |
| CN-118613472-A | Nicotinamide ester and nicotinamide riboside-based compounds and derivatives thereof | 新前沿生物公司 | 2024-09-06 | — | — | CN | disclosed |
| CN-118019801-A | Fluoropolymer compositions and methods of making the same | 阿科玛股份有限公司 | 2024-05-10 | — | — | CN | disclosed |
| US-20230097440-A1 | METHODS FOR MODULATION OF LIPOPROTEIN LIPASE AND APOLIPOPROTEIN C2 EXPRESSION AND/OR ACTIVITY IN THE TREATMENT OF PERIPHERAL AND CENTRAL NERVOUS SYSTEM TISSUE DISEASE STATES | ENDECE LLC | 2023-03-30 | — | — | US | disclosed |
| CN-113863022-A | Colored coating and artificial leather | 美利肯公司 | 2021-12-31 | — | — | CN | disclosed |
| CN-112318797-A | Colored coating and artificial leather comprising a colorant complex | 美利肯公司 | 2021-02-05 | — | — | CN | disclosed |
| US-20210024568-A1 | METHODS FOR MODULATION OF LIPOPROTEIN LIPASE AND APOLIPOPROTEIN C2 EXPRESSION AND/OR ACTIVITY IN THE TREATMENT OF PERIPHERAL AND CENTRAL NERVOUS SYSTEM TISSUE DISEASE STATES | ENDECE LLC | 2021-01-28 | — | — | US | disclosed |
| US-10723757-B2 | 6-substituted estradiol derivatives and methods of use | ENDECE LLC (US) | 2020-07-28 | — | — | US | disclosed |
| US-20190135853-A1 | 6-Substituted Estradiol Derivatives and Methods of Use | ENDECE LLC | 2019-05-09 | — | — | US | disclosed |
| US-10174070-B2 | 6-substituted estradiol derivatives and methods of use | ENDECE LLC (US) | 2019-01-08 | — | — | US | disclosed |
| EP-2616477-B1 | 6-SUBSTITUTED DEMETHYL-ESTRADIOL DERIVATIVES AS ER-BETA AGONISTS | ENDECE LLC (US) | 2016-11-09 | — | — | EP | disclosed |
| US-20160279144-A1 | 6-Substituted Estradiol Derivatives for Use in Remyelination of Nerve Axons | ENDECE LLC | 2016-09-29 | — | — | US | disclosed |
| EP-2507253-B1 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES AND METHODS OF USE | ENDECE LLC (US) | 2016-03-30 | — | — | EP | disclosed |
| EP-2688570-B1 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES FOR USE IN REMYELINATION OF NERVE AXONS | ENDECE LLC (US) | 2015-11-18 | — | — | EP | disclosed |
| WO-2015143201-A2 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ENDECE LLC (US) | 2015-09-24 | — | — | WO | disclosed |
| EP-2688570-A2 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES FOR USE IN REMYELINATION OF NERVE AXONS | Endece, LLC (US) | 2014-01-29 | — | — | EP | disclosed |
| EP-2616477-A2 | 6-SUBSTITUTED DEMETHYL-ESTRADIOL DERIVATIVES AS ER-BETA AGONISTS | Endece, LLC (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012129324-A2 | 6-SUBSTITUTED ESTRADIOL DERIVATIVES FOR USE IN REMYELINATION OF NERVE AXONS | ENDECE LLC (US) | 2012-09-27 | — | — | WO | disclosed |
| WO-2012037261-A2 | 6-SUBSTITUTED DEMETHYL-ESTRADIOL DERIVATIVES AS ER-BETA AGONISTS | ENDECE, LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| JP-H07173002-A | SEX ATTRACTANT FOR ANOMALA SCONFELDTI | NORIN SUISANSYO SANSHI KONCHIYUU NOGYO GIJUTSU KENKYUSHO | 1995-07-11 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10723757-B2 | 6-substituted estradiol derivatives and methods of use | SHBG, HSD17B11, CYP19A1 | TDP1 2410/4885CYP3A4 64/4885ESR1 5/4885 |
| US-20190135853-A1 | 6-Substituted Estradiol Derivatives and Methods of Use | SHBG, HSD17B11, CYP19A1 | TDP1 2410/4885CYP3A4 64/4885ESR1 5/4885 |
| US-20230097440-A1 | METHODS FOR MODULATION OF LIPOPROTEIN LIPASE AND APOLIPOPROTEIN C2 EXPRESSION AND/OR ACTIVITY IN THE TREATMENT OF PERIPHERAL AND CENTRAL NERVOUS SYSTEM TISSUE DISEASE STATES | LPL, LIPE, PMP22 | TDP1 1047/4885CYP3A4 2184/4885ESR1 623/4885 |
| US-10174070-B2 | 6-substituted estradiol derivatives and methods of use | NR3C2, SHBG, NR5A1 | TDP1 4863/4885CYP3A4 587/4885ESR1 17/4885 |
| US-20160279144-A1 | 6-Substituted Estradiol Derivatives for Use in Remyelination of Nerve Axons | PMP22, GAP43, MAG | TDP1 2639/4885CYP3A4 2566/4885ESR1 199/4885 |
| US-20210024568-A1 | METHODS FOR MODULATION OF LIPOPROTEIN LIPASE AND APOLIPOPROTEIN C2 EXPRESSION AND/OR ACTIVITY IN THE TREATMENT OF PERIPHERAL AND CENTRAL NERVOUS SYSTEM TISSUE DISEASE STATES | LPL, LIPE, PMP22 | TDP1 1047/4885CYP3A4 2184/4885ESR1 623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.