Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873416 | 0.80 | ANPEP (0.49) | ALDH1A1HPGDKDM4EHSD17B10MAPT | |
| SCHEMBL7868172 | 0.80 | HPGD (0.42) | ALDH1A1HPGDKDM4EHSD17B10MAPT | |
| SCHEMBL7873448 | 0.79 | MAPT (0.48) | ALDH1A1HPGDKDM4EHSD17B10MAPT | |
| SCHEMBL7879245 | 0.78 | RIOK2 (0.42) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL21072239 | 0.72 | ALDH1A1 (0.60) | ALDH1A1HPGDKDM4EHSD17B10MAPT | |
| SCHEMBL31483834 | 0.72 | ALDH1A1 (0.60) | ALDH1A1HPGDKDM4EHSD17B10MAPT | |
| SCHEMBL28269908 | 0.68 | MAPT (0.37) | ALDH1A1KDM4EMAPTRAB9ANPC1 | |
| SCHEMBL7876978 | 0.68 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4EHSD17B10MAPT | |
| SCHEMBL662027 | 0.67 | ALDH1A1 (0.61) | ALDH1A1HPGDKDM4EHSD17B10MAPT | |
| SCHEMBL12986575 | 0.67 | ALDH1A1 (0.57) | ALDH1A1HPGDKDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |