Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873394 | 0.79 | ALDH1A1 (0.49) | MAPTSMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL7873416 | 0.79 | ANPEP (0.49) | MAPTSMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL3716881 | 0.78 | MAPT (0.70) | MAPTSMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL4952246 | 0.75 | ACHE (0.41) | MAPTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL20722727 | 0.74 | KDM4E (0.62) | MAPTSMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL8554278 | 0.73 | MAPT (0.46) | MAPTSMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL4949852 | 0.73 | RAB9A (0.44) | SMN1; SMN2MEN1KMT2AKDM4ELMNA | |
| SCHEMBL3252093 | 0.72 | PPIA (0.47) | MAPTSMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL7879245 | 0.72 | RIOK2 (0.42) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL479805 | 0.72 | DHODH (0.76) | MAPTSMN1; SMN2HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |