Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIOK2 | Q9BVS4 | 6/20 | 0.42 |
| ▸ | GSK3A | P49840 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.40 |
| ▸ | SNRK | Q9NRH2 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873394 | 0.78 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7868172 | 0.77 | HPGD (0.42) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7873416 | 0.77 | ANPEP (0.49) | L3MBTL1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7873448 | 0.72 | MAPT (0.48) | L3MBTL1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30940788 | 0.68 | MEN1 (0.52) | RIOK2GSK3AMAPK10MAPK8HIPK1 | |
| SCHEMBL7879250 | 0.68 | ANPEP (0.60) | RIOK2GSK3AMAPK10MAPK8HIPK1 | |
| SCHEMBL24821175 | 0.67 | TRPV1 (0.52) | RIOK2GSK3AMAPK10MAPK8HIPK1 | |
| SCHEMBL7354818 | 0.67 | MEN1 (0.51) | RIOK2GSK3AMAPK10MAPK8HIPK1 | |
| SCHEMBL29373901 | 0.67 | RIOK2 (0.62) | RIOK2GSK3AMAPK10MAPK8HIPK1 | |
| SCHEMBL28692611 | 0.67 | RIOK2 (0.62) | RIOK2GSK3AMAPK10MAPK8HIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |