Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fletazepam SCHEMBL119540 | 0.91 | CYP3A4 (0.48) | OPRK1NR1I2ADORA3OPRM1PDE4D | |
| SCHEMBL11531856 | 0.88 | OPRK1 (0.62) | OPRK1NR1I2ADORA3OPRM1PDE4D | |
| SCHEMBL11681691 | 0.81 | OPRK1 (0.47) | OPRK1NR1I2ADORA3PDE4DADRA1A | |
| SCHEMBL9757526 | 0.78 | OPRK1 (0.59) | OPRK1NR1I2ADORA3OPRM1PDE4D | |
| SCHEMBL11680057 | 0.77 | OPRK1 (0.76) | OPRK1NR1I2ADORA3PDE4DADRA1A | |
| SCHEMBL7871700 | 0.77 | GABRA1 (0.43) | OPRK1NR1I2ADORA3OPRM1PDE4D | |
| SCHEMBL11715519 | 0.74 | GABRA1 (0.50) | OPRK1NR1I2ADORA3PDE4DADRA1A | |
| SCHEMBL11681501 | 0.74 | CYP3A4 (0.48) | OPRK1NR1I2ADORA3PDE4DADRA1A | |
| SCHEMBL11468031 | 0.72 | OPRK1 (0.48) | OPRK1NR1I2ADORA3PDE4DADRA1A | |
| SCHEMBL9848803 | 0.72 | CYP3A4 (0.51) | OPRK1NR1I2ADORA3OPRM1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048857-A | TRIFLUOROBENZODIAZEPINE | ELLINWOOD JR EVERETT H (US) | 2000-04-11 | — | — | US | claimed |
| EP-0428272-A2 | Trifluorobenzodiazepine compounds for use in therapy by intraoral administration | Ellinwood, Everett Hews (US) | 1991-05-22 | — | — | EP | claimed |
| US-6313176-B1 | SELECTING AN IRREVERSIBLE ENZYME INHIBITOR AS A MEDICAMENT THAT IS METABOLIZED INTO AN UNWANTED OR ADVERSIVE METABOLITE; PLACING IRREVERSIBLE ENZYME INHIBITOR IN A SUITABLE FORMULATION; ADMINISTERING FORMULATION FOR THERAPY | ELLINWOOD JR EVERETT J (US) | 2001-11-06 | — | — | US | disclosed |
| US-6140323-A | SELECTING DRUG; PLACING FOR INHALATION OR SKIN ADMINISTRATION FORMAULATION; ADMINISTERING FORMULATION SO AS TO BYPASS GASTROINTESTINAL ABSORPTION AND PORTAL VEIN ENTRY TO LIVER TO DECREASE FORMATION OF UNWANTED METABOLITE | ELLINWOOD JR EVERETT H (US) | 2000-10-31 | — | — | US | disclosed |
| US-6048857-A | TRIFLUOROBENZODIAZEPINE | ELLINWOOD JR EVERETT H (US) | 2000-04-11 | — | — | US | disclosed |