Fletazepam

Fletazepam

SCHEMBL119540

Fc1ccccc1C1=NCCN(CC(F)(F)F)c2ccc(Cl)cc21

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.48
OPRK1 P41145 4/20 0.48
DRD3 P35462 2/20 0.48
PDE4D Q08499 2/20 0.48
SLC22A1 O15245 1/20 0.48
ABCB11 O95342 1/20 0.48
HTR1A P08908 1/20 0.47
HTR3A P46098 1/20 0.47
KCNH2 Q12809 1/20 0.47
GHSR Q92847 1/20 0.47
NR1I2 O75469 2/20 0.47
ADORA3 P0DMS8 2/20 0.47
OPRM1 P35372 1/20 0.47
HTR2C P28335 1/20 0.46
ADRA1A P35348 1/20 0.46
PTGS2 P35354 1/20 0.46
CHRNA4 P43681 1/20 0.46
SLC6A3 Q01959 1/20 0.46
CHRM1 P11229 1/20 0.43
LMNA P02545 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7873579 0.91 OPRK1 (0.48) OPRK1PDE4DNR1I2ADORA3OPRM1
SCHEMBL7871700 0.86 GABRA1 (0.43) CYP3A4OPRK1DRD3PDE4DSLC22A1
SCHEMBL11531856 0.86 OPRK1 (0.62) OPRK1PDE4DKCNH2NR1I2ADORA3
SCHEMBL11681501 0.83 CYP3A4 (0.48) CYP3A4OPRK1DRD3PDE4DSLC22A1
SCHEMBL11536241 0.80 OPRK1 (0.70) CYP3A4OPRK1DRD3PDE4DSLC22A1
SCHEMBL9848803 0.79 CYP3A4 (0.51) CYP3A4OPRK1DRD3PDE4DSLC22A1
Hydrochloric Acid SCHEMBL11683071 0.79 OPRK1 (0.69) CYP3A4OPRK1DRD3PDE4DSLC22A1
Quazepam SCHEMBL29504 0.78 OPRK1 (0.58) CYP3A4OPRK1DRD3PDE4DSLC22A1
Quazepam SCHEMBL29534458 0.78 OPRK1 (0.58) CYP3A4OPRK1DRD3PDE4DSLC22A1
SCHEMBL5379874 0.78 OPRK1 (0.77) CYP3A4OPRK1DRD3PDE4DSLC22A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 294 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
EP-0428272-A2 Trifluorobenzodiazepine compounds for use in therapy by intraoral administration Ellinwood, Everett Hews (US) 1991-05-22 EP claimed
US-4155904-A Process for the preparation of 1,4-benzo-diazepines and 1,4-benzodiazepinones SCHERING CORPORATION (US) 1979-05-22 US claimed
US-20260137765-A1 METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STXB) MONOMERS AND OLIGOMERS, AND USES THEREOF INSTITUT CURIE (FR) 2026-05-21 US disclosed
EP-4706683-A2 CHEWABLE FORMULATIONS Elanco Tiergesundheit AG (CH) 2026-03-11 EP disclosed
US-20260034059-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES AQUESTIVE THERAPEUTICS, INC. (US) 2026-02-05 US disclosed
US-12527854-B2 Methods of producing Shiga toxin B-subunit (STxB) monomers and oligomers, and uses thereof INSTITUT CURIE (FR) 2026-01-20 US disclosed
EP-0909183-A2 DHA-PHARMACEUTICAL AGENT CONJUGATES Neuromedica, Inc. (US) 1999-04-21 EP disclosed
US-5795909-A ANTICARCINOGENIC AND ANTITUMOR AGENTS; BREAST, COLON, OVARIANCANCERS NEUROMEDICA, INC. (US) 1998-08-18 US disclosed
WO-1997044063-A2 DHA-PHARMACEUTICAL AGENT CONJUGATES NEUROMEDICA, INC. (US) 1997-11-27 WO disclosed
US-4155904-A Process for the preparation of 1,4-benzo-diazepines and 1,4-benzodiazepinones SCHERING CORPORATION (US) 1979-05-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12527854-B2 Methods of producing Shiga toxin B-subunit (STxB) monomers and oligomers, and uses thereof STXBP1, RNGTT, UPF1 CYP3A4 4776/4885OPRK1 3689/4885DRD3 2949/4885
US-20260137765-A1 METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STXB) MONOMERS AND OLIGOMERS, AND USES THEREOF STXBP1, HBB, UPF1 CYP3A4 4764/4885OPRK1 3285/4885DRD3 2318/4885
US-20260034059-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES SORD, SLC6A13, CACNA1A CYP3A4 143/4885OPRK1 2725/4885DRD3 946/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.