Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.65 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18648120 | 1.00 | NPC1 (0.68) | NPC1RAB9APOLBEPHX2EPHX1 | |
| SCHEMBL7105933 | 0.92 | LMNA (0.63) | NPC1RAB9APOLBEPHX2EPHX1 | |
| SCHEMBL19982101 | 0.87 | RAB9A (0.59) | NPC1RAB9APOLBEPHX2EPHX1 | |
| SCHEMBL3026453 | 0.87 | KDM1A (0.53) | NPC1RAB9APOLBEPHX2EPHX1 | |
| SCHEMBL17729947 | 0.81 | EPHX2 (0.52) | NPC1RAB9AEPHX2ALDH1A1MEN1 | |
| SCHEMBL17729946 | 0.81 | EPHX2 (0.52) | NPC1RAB9AEPHX2ALDH1A1MEN1 | |
| SCHEMBL9325905 | 0.81 | NPC1 (1.00) | NPC1RAB9APOLBEPHX2EPHX1 | |
| SCHEMBL3637147 | 0.80 | L3MBTL1 (0.57) | — | |
| SCHEMBL23686078 | 0.80 | NPC1 (0.73) | NPC1RAB9APOLBEPHX2ALDH1A1 | |
| SCHEMBL15652941 | 0.80 | RAB9A (0.73) | NPC1RAB9APOLBEPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326500-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | ABBOTT LABORATORIES | 2001-12-04 | — | — | US | disclosed |
| US-6215001-B1 | ANTIINFLAMMATORY AGENTS, ANTIASTHMATICS, AND ANTIALLERGENS; SIDE EFFECT REDUCTION | KNOLL AKTIENGESELLSCHAFT (DE) | 2001-04-10 | — | — | US | disclosed |
| US-6031109-A | Phenoxy-, phenylthio-, benzoyl-alkyleneaminoalkylene-imidazole derivatives as therapeutic agents | KNOLL AKTIENGESELLSCHAFT (DE) | 2000-02-29 | — | — | US | disclosed |
| US-5780642-A | NON-STEROIDAL ANTIINFLAMMATORY AGENT WHICH BLOCKS RELEASE OF ARACHIDONIC ACID FROM PHOSPHOLIPIDS; SIDE EFFECT REDUCTION | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| EP-0705251-A1 | IMIDAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000493-A1 | IMIDAZOLE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |