Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 11/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | PEPD | P12955 | 2/20 | 0.42 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775248 | 1.00 | FKBP1A (0.64) | FKBP1APOLBALOX5PEPDXPNPEP1 | |
| SCHEMBL2006947 | 0.95 | FKBP1A (0.58) | FKBP1APOLBALOX5PEPDXPNPEP1 | |
| SCHEMBL7245076 | 0.87 | FKBP1A (0.50) | FKBP1APOLBALOX5PEPDXPNPEP1 | |
| SCHEMBL10034603 | 0.86 | FKBP1A (0.57) | FKBP1APOLB | |
| SCHEMBL1774605 | 0.86 | FKBP1A (0.58) | FKBP1APEPDLMNARAB9A | |
| SCHEMBL5833327 | 0.86 | FKBP1A (0.68) | FKBP1AALDH1A1 | |
| SCHEMBL611148 | 0.86 | FKBP1A (0.68) | FKBP1AALDH1A1 | |
| SCHEMBL4484566 | 0.84 | FKBP1A (0.56) | FKBP1APOLBALOX5PEPDXPNPEP1 | |
| SCHEMBL3061683 | 0.82 | FKBP1A (0.57) | FKBP1APOLBPEPDXPNPEP1ALDH1A1 | |
| SCHEMBL5965365 | 0.82 | FKBP1A (0.57) | FKBP1APOLBPEPDXPNPEP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943775-B2 | to detect amyloid deposits prior to aggregation into plaques; labeled bifunctional compound binds to target protein and to chaperone protein; Alzheimer's; 1-[4-(carboxymethoxy)phenyl]-3-(3,4-dimethoxy-phenyl)-1-propanyl-1-(3,3-dimethyl-1,2-dioxopentyl)-2-piperidinecarboxylate isomers bind differently | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-05-17 | — | — | US | disclosed |
| US-20090162858-A1 | Orthogonal chemical inducer of dimerization | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2009-06-25 | — | — | US | disclosed |
| US-20090162858-A1 | Orthogonal chemical inducer of dimerization | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2009-06-25 | — | — | US | disclosed |
| US-20080085238-A1 | Small Molecules for Imaging Protein-Protein Interactions | The Government of the United States of America as represented (US) | 2008-04-10 | — | — | US | disclosed |
| US-6316405-B1 | CYCLOSPORIN A, POLYPEPTIDES, COMPONENT OF AMYLOID PLAQUES FOUND IN NEUROLOGICAL DISORDERS SUCH AS ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, AND AMYOTROPHIC LATERAL SCLEROSIS. THE CONJUGATES ARE USEFUL IN THE TREATMENT OF NEUROLOGICAL | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2001-11-13 | — | — | US | disclosed |
| WO-1999010374-A1 | CYCLOSPORIN A CONJUGATES AND USES THEREFOR | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085238-A1 | Small Molecules for Imaging Protein-Protein Interactions | HSPBP1, HSPA2, HSPA8 | FKBP1A 1547/4885POLB 4361/4885ALOX5 4857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.