Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 8/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | PEPD | P12955 | 2/20 | 0.46 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775248 | 0.95 | FKBP1A (0.64) | FKBP1APOLBALOX5PEPDXPNPEP1 | |
| SCHEMBL7874672 | 0.95 | FKBP1A (0.64) | FKBP1APOLBALOX5PEPDXPNPEP1 | |
| SCHEMBL7245076 | 0.89 | FKBP1A (0.50) | FKBP1APOLBALOX5PEPDXPNPEP1 | |
| SCHEMBL13878779 | 0.87 | FKBP1A (0.57) | FKBP1APOLBALOX5PEPDXPNPEP1 | |
| SCHEMBL20253015 | 0.86 | FKBP1A (0.51) | FKBP1APOLBALOX5RAB9A | |
| SCHEMBL3154647 | 0.86 | FKBP1A (0.52) | FKBP1APEPDALDH1A1LMNARAB9A | |
| SCHEMBL9650460 | 0.86 | FKBP1A (0.52) | FKBP1APEPDALDH1A1LMNARAB9A | |
| SCHEMBL7434434 | 0.86 | FKBP1A (0.52) | FKBP1APEPDALDH1A1LMNARAB9A | |
| SCHEMBL13878778 | 0.85 | FKBP1A (0.57) | FKBP1APOLBALOX5PEPDXPNPEP1 | |
| SCHEMBL22356082 | 0.84 | POLB (0.56) | FKBP1APOLBALOX5PEPDXPNPEP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960570-B2 | Small molecule inhibitors of rotamase enzyme activity | GLIAMED, INC. (US) | 2011-06-14 | — | — | US | claimed |
| US-20100145071-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GLIAMED, INC. (US) | 2010-06-10 | — | — | US | claimed |
| EP-1433781-B1 | Pyrrolidine carboxylic acid derivatives | MGI GP INC (US) | 2010-02-24 | — | — | EP | claimed |
| EP-1433781-A1 | Pyrrolidine carboxylic acid derivatives | GPI NIL Holdings, Inc. (US) | 2004-06-30 | — | — | EP | claimed |
| US-20110218343-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GLIAMED, INC. (US) | 2011-09-08 | — | — | US | disclosed |
| US-20110218343-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GLIAMED, INC. (US) | 2011-09-08 | — | — | US | disclosed |
| US-20110218343-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GLIAMED, INC. (US) | 2011-09-08 | — | — | US | disclosed |
| US-7960570-B2 | Small molecule inhibitors of rotamase enzyme activity | GLIAMED, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-7960570-B2 | Small molecule inhibitors of rotamase enzyme activity | GLIAMED, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-7960570-B2 | Small molecule inhibitors of rotamase enzyme activity | GLIAMED, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20100330063-A1 | STEM-LIKE CELLS, METHOD FOR DE-DIFFERENTIATING MAMMALIAN SOMATIC CELLS INTO STEM-LIKE CELLS, AND METHOD FOR DIFFERENTIATING STEM-LIKE CELLS | GLIAMED, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100330063-A1 | STEM-LIKE CELLS, METHOD FOR DE-DIFFERENTIATING MAMMALIAN SOMATIC CELLS INTO STEM-LIKE CELLS, AND METHOD FOR DIFFERENTIATING STEM-LIKE CELLS | GLIAMED, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| EP-1104299-A2 | N-LINKED UREA OR CARBAMATE OF HETEROCYCLIC THIOESTERS FOR VISION AND MEMORY DISORDERS | GPI NIL Holdings, Inc. (US) | 2001-06-06 | — | — | EP | disclosed |
| US-6218424-B1 | FOR EFFECTING NEURONAL ACTIVITIES IN ANIMALS, INCLUDING TREATING NEUROLOGICAL DISORDERS | GPI NIL HOLDINGS, INC. | 2001-04-17 | — | — | US | disclosed |
| US-6172087-B1 | TREATING ALOPECIA | GPI NIL HOLDING, INC. | 2001-01-09 | — | — | US | disclosed |
| CN-1275977-A | Heterocyclic thioesters and ketones | GPI NIL HOLDING CO (US) | 2000-12-06 | — | — | CN | disclosed |
| WO-2000009484-A1 | PIPECOLIC ACID DERIVATIVES AND THEIR USE FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2000-02-24 | — | — | WO | disclosed |
| WO-2000009110-A2 | N-LINKED UREA OR CARBAMATE OF HETEROCYCLIC THIOESTERS FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS INC. (US) | 2000-02-24 | — | — | WO | disclosed |
| WO-2000009108-A2 | COMPOSITIONS AND USES FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2000-02-24 | — | — | WO | disclosed |
| US-5990131-A | OF GIVEN FORMULA WHICH HAVE A HIGH AFFINITY FOR FKBPS (FK506 BINDING PROTEINS, A CLASS OF IMMUNOPHILINS) ARE POTENT ROTAMASE INHIBITORS AND EXHIBIT EXCELLENT NEUROTROPHIC EFFECTS; NO IMMUNOSUPPRESSIVE ACTIVITY | GPI NIL HOLDINGS INC. (US) | 1999-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145071-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | FKBP8, FKBP1A, FKBP2 | FKBP1A 2/4885POLB 3306/4885ALOX5 4723/4885 |
| US-20100330063-A1 | STEM-LIKE CELLS, METHOD FOR DE-DIFFERENTIATING MAMMALIAN SOMATIC CELLS INTO STEM-LIKE CELLS, AND METHOD FOR DIFFERENTIATING STEM-LIKE CELLS | POU2F1, POU2F2, POU5F1 | FKBP1A 4746/4885POLB 2401/4885ALOX5 4685/4885 |
| US-20110218343-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | FKBP8, FKBP1A, FKBP2 | FKBP1A 2/4885POLB 3306/4885ALOX5 4723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.