Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | MME | P08473 | 7/20 | 0.44 |
| ▸ | ACE | P12821 | 5/20 | 0.44 |
| ▸ | CPA1 | P15085 | 2/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | FCER2 | P06734 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | TLL1 | O43897 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879214 | 0.86 | SLC1A3 (0.49) | MMEACESLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7879220 | 0.81 | KMT2A (0.42) | PPARGPPARAMMEACECPA1 | |
| SCHEMBL7876572 | 0.76 | BMP1 (0.34) | PPARGPPARAMMEACECPA1 | |
| SCHEMBL7876984 | 0.76 | SLC1A3 (0.43) | MMESLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7387885 | 0.76 | TLL1 (0.42) | PPARGPPARAACETLL1BMP1 | |
| SCHEMBL7868080 | 0.75 | TLL1 (0.43) | PPARGTLL1BMP1MMP12TLL2 | |
| SCHEMBL7868067 | 0.74 | SLC1A1 (0.40) | PPARAMMEACESLC1A3SLC1A2 | |
| SCHEMBL7874743 | 0.74 | CYP2C19 (0.48) | SLC1A3SLC1A2SLC1A1MMP9TLL1 | |
| SCHEMBL7876948 | 0.74 | SLC1A3 (0.40) | SLC1A3SLC1A2SLC1A1MEN1KMT2A | |
| SCHEMBL5052927 | 0.74 | PPARG (0.43) | PPARGPPARAMMEACECPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |