Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 2/20 | 0.34 |
| ▸ | MMP12 | P39900 | 2/20 | 0.34 |
| ▸ | TLL1 | O43897 | 1/20 | 0.34 |
| ▸ | TLL2 | Q9Y6L7 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | ACE | P12821 | 2/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | CPA1 | P15085 | 1/20 | 0.31 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879214 | 0.79 | SLC1A3 (0.49) | BMP1MMP12TLL1TLL2ACE | |
| SCHEMBL7874813 | 0.76 | PPARG (0.44) | BMP1MMP12TLL1TLL2PPARG | |
| SCHEMBL7876948 | 0.76 | SLC1A3 (0.40) | BMP1MMP12TLL1TLL2 | |
| SCHEMBL7874743 | 0.74 | CYP2C19 (0.48) | BMP1MMP12TLL1TLL2MMP3 | |
| SCHEMBL7876857 | 0.73 | NR4A2 (0.40) | BMP1MMP12TLL1TLL2 | |
| SCHEMBL7873397 | 0.71 | MMP3 (0.45) | BMP1MMP12TLL1TLL2MMP3 | |
| SCHEMBL7387885 | 0.71 | TLL1 (0.42) | BMP1MMP12TLL1TLL2PPARG | |
| SCHEMBL7879220 | 0.71 | KMT2A (0.42) | BMP1MMP12TLL1TLL2PPARG | |
| SCHEMBL7868080 | 0.70 | TLL1 (0.43) | BMP1MMP12TLL1TLL2PPARG | |
| SCHEMBL7876984 | 0.69 | SLC1A3 (0.43) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |