Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TLL1 | O43897 | 1/20 | 0.35 |
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | TLL2 | Q9Y6L7 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868114 | 0.90 | SLC1A3 (0.41) | SLC1A3SLC1A2SLC1A1MEN1KMT2A | |
| SCHEMBL7879214 | 0.81 | SLC1A3 (0.49) | SLC1A3SLC1A2SLC1A1TLL1BMP1 | |
| SCHEMBL7874743 | 0.78 | CYP2C19 (0.48) | SLC1A3SLC1A2SLC1A1ALDH1A1TLL1 | |
| SCHEMBL7876572 | 0.76 | BMP1 (0.34) | TLL1BMP1MMP12TLL2 | |
| SCHEMBL7873397 | 0.76 | MMP3 (0.45) | TLL1BMP1MMP12TLL2RIPK1 | |
| SCHEMBL7879220 | 0.75 | KMT2A (0.42) | SLC1A3SLC1A2SLC1A1KMT2AALDH1A1 | |
| SCHEMBL7874813 | 0.74 | PPARG (0.44) | SLC1A3SLC1A2SLC1A1MEN1KMT2A | |
| SCHEMBL7876984 | 0.73 | SLC1A3 (0.43) | SLC1A3SLC1A2SLC1A1PTGS1PTGS2 | |
| SCHEMBL1532410 | 0.73 | TDP1 (0.47) | SLC1A3SLC1A2SLC1A1MEN1KMT2A | |
| SCHEMBL7876857 | 0.73 | NR4A2 (0.40) | MEN1KMT2AMAPTTLL1BMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |