SCHEMBL7874743

SCHEMBL7874743

CCC[C@@H]([C@@H](Cc1cccs1)C(=O)O)N(O)C=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.48
SLC1A3 P43003 1/20 0.40
SLC1A2 P43004 1/20 0.40
SLC1A1 P43005 1/20 0.40
RAB9A P51151 1/20 0.38
CTSC P53634 1/20 0.38
ALDH1A1 P00352 1/20 0.36
POLB P06746 2/20 0.36
TRPM8 Q7Z2W7 1/20 0.36
MMP3 P08254 2/20 0.35
MMP9 P14780 2/20 0.35
ADAM17 P78536 2/20 0.35
TAS1R3 Q7RTX0 1/20 0.35
TAS1R1 Q7RTX1 1/20 0.35
TLL1 O43897 1/20 0.35
BMP1 P13497 1/20 0.35
MMP12 P39900 1/20 0.35
TLL2 Q9Y6L7 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
RIPK1 Q13546 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7876864 0.88 CYP2C19 (0.40) CYP2C19SLC1A3SLC1A2SLC1A1RAB9A
SCHEMBL7879214 0.81 SLC1A3 (0.49) SLC1A3SLC1A2SLC1A1POLBTLL1
SCHEMBL7873397 0.81 MMP3 (0.45) TRPM8MMP3MMP9ADAM17TAS1R3
SCHEMBL7876984 0.78 SLC1A3 (0.43) SLC1A3SLC1A2SLC1A1TAS1R3TAS1R1
SCHEMBL7876948 0.78 SLC1A3 (0.40) SLC1A3SLC1A2SLC1A1RAB9AALDH1A1
SCHEMBL7877005 0.76 CYP2C19 (0.41) CYP2C19SLC1A3SLC1A2SLC1A1ALDH1A1
SCHEMBL7879220 0.75 KMT2A (0.42) SLC1A3SLC1A2SLC1A1ALDH1A1POLB
SCHEMBL7874813 0.74 PPARG (0.44) SLC1A3SLC1A2SLC1A1MMP9TLL1
SCHEMBL7876572 0.74 BMP1 (0.34) MMP3MMP9ADAM17TLL1BMP1
SCHEMBL7876857 0.73 NR4A2 (0.40) RAB9ATAS1R3TAS1R1TLL1BMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6329400-B1 INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS GLAXO WELLCOME INC. 2001-12-11 US disclosed