Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874873 | 1.00 | ADORA3 (0.46) | ADORA3HTR2AHTR7OPRM1SIGMAR1 | |
| SCHEMBL7874875 | 1.00 | ADORA3 (0.46) | ADORA3HTR2AHTR7OPRM1SIGMAR1 | |
| SCHEMBL7872003 | 0.84 | ADORA3 (0.41) | ADORA3HTR2AHTR7OPRM1SIGMAR1 | |
| SCHEMBL7872004 | 0.84 | ADORA3 (0.41) | ADORA3HTR2AHTR7OPRM1SIGMAR1 | |
| SCHEMBL3932037 | 0.84 | PPARG (0.45) | ADORA3HTR2AHTR7OPRM1SIGMAR1 | |
| SCHEMBL16897790 | 0.77 | LMNA (0.48) | ADORA3HTR2AHTR7OPRM1SIGMAR1 | |
| SCHEMBL30716259 | 0.76 | SMN1; SMN2 (0.48) | L3MBTL1SMN1; SMN2NPC1RAB9ACHRM1 | |
| SCHEMBL29584843 | 0.76 | KMT2A (0.46) | ADORA3HTR2AHTR7OPRM1SIGMAR1 | |
| SCHEMBL6983413 | 0.76 | L3MBTL1 (0.62) | L3MBTL1MEN1KMT2AHRH3SMN1; SMN2 | |
| SCHEMBL13575597 | 0.76 | SMN1; SMN2 (0.60) | MEN1KMT2AGRIN2BSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303593-B1 | FOR THERAPY HUMAN IMMUNODEFICIENCY VIRUS INFECTION, AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFLAMMATORY AND IMMUNOREGULATORY DISORDER OR DISEASE, ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS | MERCK & CO., INC. | 2001-10-16 | — | — | US | disclosed |