Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2940461 | 0.92 | ALOX5 (0.48) | ALOX5DRD4AHRKDM4ECYP19A1 | |
| SCHEMBL787256 | 0.82 | ALOX5 (0.59) | ALOX5DRD4AHRKDM4ECYP19A1 | |
| SCHEMBL10109859 | 0.81 | ALOX5 (0.58) | ALOX5DRD4AHRKDM4ECYP19A1 | |
| SCHEMBL17196260 | 0.81 | ALOX5 (0.58) | ALOX5DRD4AHRKDM4ECYP19A1 | |
| SCHEMBL7962346 | 0.81 | ALOX5 (0.54) | ALOX5DRD4AHRKDM4ECYP19A1 | |
| SCHEMBL7035976 | 0.78 | ALDH1A1 (0.43) | ALOX5AHRKDM4ECYP19A1CYP11B1 | |
| SCHEMBL21436953 | 0.78 | ALOX5 (0.51) | ALOX5DRD4AHRKDM4ECYP19A1 | |
| SCHEMBL20982326 | 0.78 | ALOX5 (0.51) | ALOX5DRD4KDM4EMEN1KMT2A | |
| SCHEMBL8374054 | 0.78 | ALOX5 (0.55) | ALOX5DRD4AHRKDM4ECYP19A1 | |
| SCHEMBL19768712 | 0.78 | ALOX5 (0.51) | ALOX5DRD4AHRKDM4ECYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963028-B1 | PIPERAZINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ATIR HOLDING S A (LU) | 2018-08-01 | — | — | EP | disclosed |
| US-9278957-B2 | Piperazine, piperidine and tetrahydropyridine derivatives and their pharmaceutical use | ATIR HOLDING S.A. (LU) | 2016-03-08 | — | — | US | disclosed |
| US-9278957-B2 | Piperazine, piperidine and tetrahydropyridine derivatives and their pharmaceutical use | ATIR HOLDING S.A. (LU) | 2016-03-08 | — | — | US | disclosed |
| US-9278957-B2 | Piperazine, piperidine and tetrahydropyridine derivatives and their pharmaceutical use | ATIR HOLDING S.A. (LU) | 2016-03-08 | — | — | US | disclosed |
| EP-2963028-A1 | PIPERAZINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | Atir Holding S.A. (LU) | 2016-01-06 | — | — | EP | disclosed |
| EP-2435414-B1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ATIR HOLDING S A (LU) | 2015-08-19 | — | — | EP | disclosed |
| US-20150099784-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GROEN AERONAUTICS CORPORATION | 2015-04-09 | — | — | US | disclosed |
| US-20150099784-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GROEN AERONAUTICS CORPORATION | 2015-04-09 | — | — | US | disclosed |
| US-20150099784-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GROEN AERONAUTICS CORPORATION | 2015-04-09 | — | — | US | disclosed |
| US-8912196-B2 | Piperazine, piperidine and tetrahydropyridine derivatives and their pharmaceutical use | ATIR HOLDING S.A. (LU) | 2014-12-16 | — | — | US | disclosed |
| US-8912196-B2 | Piperazine, piperidine and tetrahydropyridine derivatives and their pharmaceutical use | ATIR HOLDING S.A. (LU) | 2014-12-16 | — | — | US | disclosed |
| US-8912196-B2 | Piperazine, piperidine and tetrahydropyridine derivatives and their pharmaceutical use | ATIR HOLDING S.A. (LU) | 2014-12-16 | — | — | US | disclosed |
| US-20120071487-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ATIR HOLDING S.A. | 2012-03-22 | — | — | US | disclosed |
| US-20120071487-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ATIR HOLDING S.A. | 2012-03-22 | — | — | US | disclosed |
| US-20120071487-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ATIR HOLDING S.A. | 2012-03-22 | — | — | US | disclosed |
| WO-2010137018-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ATIR HOLDING S.A. (LU) | 2010-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099784-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | DPYD, BRPF3, BRPF1 | ALOX5 2150/4885DRD4 32/4885AHR 293/4885 |
| US-20120071487-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | DPYD, BRPF3, BRPF1 | ALOX5 2150/4885DRD4 32/4885AHR 293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.