Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7872378 | 0.91 | ALDH1A1 (0.41) | ALDH1A1HTTRAB9AMAPTKMT2A | |
| SCHEMBL6677458 | 0.88 | ALDH1A1 (0.41) | ALDH1A1HTTRAB9AMAPTLMNA | |
| SCHEMBL6676029 | 0.83 | TDP1 (0.46) | ALDH1A1HTTRAB9AKMT2AMEN1 | |
| SCHEMBL6679943 | 0.81 | NR1D1 (0.40) | ALDH1A1HTTRAB9ASMN1; SMN2NR1D1 | |
| SCHEMBL7872408 | 0.80 | HDAC1 (0.34) | ALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL283204 | 0.80 | SMN1; SMN2 (0.42) | ALDH1A1HTTMAPTKMT2AMEN1 | |
| SCHEMBL16961950 | 0.76 | RECQL (0.48) | ALDH1A1HTTRAB9AMAPTKMT2A | |
| SCHEMBL1627019 | 0.75 | TSHR (0.44) | ALDH1A1MAPTKMT2ANR1D1L3MBTL1 | |
| SCHEMBL1625905 | 0.75 | BMP1 (0.47) | ALDH1A1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL19450307 | 0.75 | ALDH1A1 (0.39) | ALDH1A1HTTRAB9AMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | disclosed |