Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 2/20 | 0.37 |
| ▸ | MMP12 | P39900 | 2/20 | 0.37 |
| ▸ | TLL1 | O43897 | 1/20 | 0.37 |
| ▸ | TLL2 | Q9Y6L7 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 8/20 | 0.36 |
| ▸ | MMP3 | P08254 | 7/20 | 0.36 |
| ▸ | MMP9 | P14780 | 7/20 | 0.36 |
| ▸ | MMP1 | P03956 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7387885 | 0.82 | TLL1 (0.42) | BMP1MMP12TLL1TLL2PTGES | |
| SCHEMBL7868133 | 0.81 | TDP1 (0.45) | — | |
| SCHEMBL7868080 | 0.79 | TLL1 (0.43) | BMP1MMP12TLL1TLL2PTGES | |
| SCHEMBL7876864 | 0.79 | CYP2C19 (0.40) | BMP1MMP12TLL1TLL2ADAM17 | |
| SCHEMBL7873420 | 0.75 | BMP1 (0.39) | BMP1MMP12TLL1TLL2ALOX5 | |
| SCHEMBL7876988 | 0.75 | SLC1A3 (0.41) | BMP1MMP12TLL1TLL2PTGES | |
| SCHEMBL7876551 | 0.74 | ALDH1A1 (0.38) | BMP1MMP12TLL1TLL2HDAC1 | |
| SCHEMBL7879226 | 0.73 | BMP1 (0.47) | BMP1MMP12TLL1TLL2PTGES | |
| SCHEMBL7879214 | 0.73 | SLC1A3 (0.49) | BMP1MMP12TLL1TLL2HDAC3 | |
| SCHEMBL7876860 | 0.72 | BMP1 (0.40) | BMP1MMP12TLL1TLL2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |