Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | TLL1 | O43897 | 1/20 | 0.38 |
| ▸ | BMP1 | P13497 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | TLL2 | Q9Y6L7 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | MC5R | P33032 | 1/20 | 0.35 |
| ▸ | MC3R | P41968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874743 | 0.88 | CYP2C19 (0.48) | CYP2C19SLC1A3SLC1A2SLC1A1TLL1 | |
| SCHEMBL7877005 | 0.86 | CYP2C19 (0.41) | CYP2C19SLC1A3SLC1A2SLC1A1POLB | |
| SCHEMBL7387885 | 0.83 | TLL1 (0.42) | CYP2C19TLL1BMP1MMP12TLL2 | |
| SCHEMBL7876988 | 0.81 | SLC1A3 (0.41) | SLC1A3SLC1A2SLC1A1TLL1BMP1 | |
| SCHEMBL7868080 | 0.80 | TLL1 (0.43) | TLL1BMP1MMP12TLL2 | |
| SCHEMBL7876934 | 0.79 | BMP1 (0.37) | TLL1BMP1MMP12TLL2ADAM17 | |
| SCHEMBL7876551 | 0.78 | ALDH1A1 (0.38) | TLL1BMP1MMP12TLL2POLB | |
| SCHEMBL7873420 | 0.78 | BMP1 (0.39) | SLC1A3SLC1A2SLC1A1TLL1BMP1 | |
| SCHEMBL7868133 | 0.76 | TDP1 (0.45) | TDP1 | |
| SCHEMBL7876860 | 0.75 | BMP1 (0.40) | SLC1A3SLC1A2SLC1A1TLL1BMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |