Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 2/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | BMP1 | P13497 | 2/20 | 0.35 |
| ▸ | MMP12 | P39900 | 2/20 | 0.35 |
| ▸ | TLL1 | O43897 | 1/20 | 0.35 |
| ▸ | TLL2 | Q9Y6L7 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876984 | 0.87 | SLC1A3 (0.43) | SLC1A3SLC1A2SLC1A1DRD2DRD3 | |
| SCHEMBL7387885 | 0.84 | TLL1 (0.42) | PTGESALOX5BMP1MMP12TLL1 | |
| SCHEMBL7868080 | 0.81 | TLL1 (0.43) | PTGESALOX5BMP1MMP12TLL1 | |
| SCHEMBL7876864 | 0.81 | CYP2C19 (0.40) | SLC1A3SLC1A2SLC1A1BMP1MMP12 | |
| SCHEMBL7873420 | 0.80 | BMP1 (0.39) | SLC1A3SLC1A2SLC1A1ALOX5BMP1 | |
| SCHEMBL7868133 | 0.78 | TDP1 (0.45) | — | |
| SCHEMBL7876860 | 0.76 | BMP1 (0.40) | SLC1A3SLC1A2SLC1A1ALOX5BMP1 | |
| SCHEMBL7879226 | 0.76 | BMP1 (0.47) | PTGESALOX5BMP1MMP12TLL1 | |
| SCHEMBL7876551 | 0.75 | ALDH1A1 (0.38) | ALOX5OPRM1OPRD1OPRK1BMP1 | |
| SCHEMBL7876934 | 0.75 | BMP1 (0.37) | PTGESALOX5BMP1MMP12TLL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |