Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.32 |
| ▸ | USP19 | O94966 | 7/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873415 | 0.78 | SLC6A3 (0.36) | IDO1CTSS | |
| SCHEMBL7393950 | 0.69 | SLC18A3 (0.34) | IDO1CTSS | |
| SCHEMBL7359462 | 0.69 | IDO1 (0.42) | IDO1SIGMAR1 | |
| SCHEMBL7876535 | 0.67 | IDO1 (0.39) | PSMB5PSMB2IDO1 | |
| SCHEMBL7429163 | 0.66 | METAP2 (0.41) | PSMB5PSMB2CTSS | |
| SCHEMBL5762361 | 0.61 | SLC18A3 (0.44) | PSMB5PSMB2IDO1 | |
| SCHEMBL24663869 | 0.60 | IDO1 (0.51) | IDO1 | |
| SCHEMBL13008024 | 0.60 | IDO1 (0.55) | IDO1 | |
| SCHEMBL10197495 | 0.60 | IDO1 (0.55) | IDO1 | |
| SCHEMBL5762356 | 0.59 | ALDH1A1 (0.44) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |