Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA5 | P11021 | 8/20 | 0.52 |
| ▸ | HSPA2 | P54652 | 4/20 | 0.52 |
| ▸ | HSPA9 | P38646 | 2/20 | 0.52 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13694245 | 0.78 | MAPK8 (0.63) | LMNAKDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7873432 | 0.78 | TSHR (0.51) | PKMLMNACYP1A2SMN1; SMN2TSHR | |
| SCHEMBL7357770 | 0.76 | PKM (0.50) | PKMLMNAKDM4ECYP1A2CYP3A4 | |
| SCHEMBL6248227 | 0.76 | PKM (0.50) | PKMLMNAKDM4ECYP1A2CYP3A4 | |
| SCHEMBL6248230 | 0.76 | PKM (0.50) | PKMLMNAKDM4ECYP1A2CYP3A4 | |
| SCHEMBL9072828 | 0.76 | HSPA5 (0.49) | HSPA5HSPA9PKMLMNAXBP1 | |
| Hydrochloric Acid SCHEMBL7897131 | 0.75 | TBXAS1 (0.50) | PKMLMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL23466770 | 0.74 | HTT (0.53) | LMNA | |
| SCHEMBL23466769 | 0.74 | HTT (0.53) | LMNA | |
| SCHEMBL19000037 | 0.74 | PKM (0.48) | PKMLMNACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |