Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959565 | 0.93 | HTR1A (0.63) | HTR1ASLC6A4 | |
| SCHEMBL7877114 | 0.93 | NPC1 (0.49) | HTR1ANPC1HTR2ACCR3SLC6A4 | |
| SCHEMBL7878911 | 0.92 | CCR3 (0.49) | HTR1ANPC1HTR2ACCR3 | |
| SCHEMBL7880296 | 0.90 | HTR1A (0.48) | HTR1ANPC1SLC6A4 | |
| SCHEMBL6955648 | 0.88 | HTR2A (0.48) | HTR1AHTR2ACCR3CHRNB2CHRNB4 | |
| SCHEMBL7879034 | 0.87 | HTR1A (0.55) | HTR1ASLC6A4 | |
| SCHEMBL6947219 | 0.86 | HTR1A (0.52) | HTR1AHTR2ACCR3SLC6A4 | |
| SCHEMBL7880274 | 0.86 | HTR1A (0.55) | HTR1ASLC6A4 | |
| SCHEMBL7881308 | 0.85 | ADRA2A (0.58) | HTR1ASLC6A4 | |
| SCHEMBL7880351 | 0.85 | HTR1A (0.54) | HTR1AHTR2ACCR3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6333339-B1 | CENTRAL SYSTEM DISORDERS, SCHIZOPHRENIA AND COGNITION ACTIVATORS | MERCK PATENT GELLSCHAFT MIT BESCHRANKTER (DE) | 2001-12-25 | — | — | US | disclosed |