Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 6/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097405 | 0.84 | KDM4E (0.41) | CLK1DYRK1AEGFRNTRK1KMT2A | |
| SCHEMBL7093132 | 0.81 | HTR6 (0.37) | NTRK1ROCK1 | |
| SCHEMBL7892160 | 0.80 | EGFR (0.34) | CLK1DYRK1AEGFRENPP1 | |
| SCHEMBL7094580 | 0.80 | RAB9A (0.46) | EGFRNAMPTLRRK2 | |
| SCHEMBL7090927 | 0.79 | GAA (0.46) | EGFRMEN1KMT2ACNR2 | |
| SCHEMBL7096045 | 0.79 | LRRK2 (0.43) | DYRK1AEGFRNAMPTROCK1LRRK2 | |
| SCHEMBL7092191 | 0.76 | CXCR4 (0.51) | DYRK1AEGFRNTRK1MEN1KMT2A | |
| SCHEMBL7095832 | 0.74 | AURKB (0.40) | MEN1KMT2A | |
| SCHEMBL7886097 | 0.74 | NOS2 (0.52) | EGFRMEN1KMT2ALRRK2 | |
| SCHEMBL7091910 | 0.73 | L3MBTL1 (0.46) | EGFRNTRK1MEN1KMT2AENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297238-B1 | 3-ARYL PYRAZOLES WITH 4,5(3,4)-BICYCLIC RING FUSION WHICH ARE INHIBITORS OF PROTEIN KINASES PARTICULARLY TYROSINE KINASES AND SERINE/THREONINE KINASES | BASF AKTIENGESELLSCHAFT (DE) | 2001-10-02 | — | — | US | disclosed |