Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 4/20 | 0.34 |
| ▸ | GABRD | O14764 | 4/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.34 |
| ▸ | GABRE | P78334 | 4/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18001957 | 0.65 | GPBAR1 (0.48) | GPBAR1KDM1AGABRPGABRDGABRA1 | |
| SCHEMBL14054992 | 0.64 | TMPRSS4 (0.46) | NPBWR1MCHR1KDM1AGABRPGABRD | |
| SCHEMBL5782136 | 0.62 | ALDH1A1 (0.58) | KDM1ATMPRSS4L3MBTL1ALDH1A1MAPT | |
| SCHEMBL679095 | 0.62 | ALDH1A1 (0.50) | DPP4NPBWR1MCHR1KDM1ATMPRSS4 | |
| SCHEMBL787674 | 0.60 | ALDH1A1 (0.43) | ALDH1A1GAAMAPT | |
| SCHEMBL18770617 | 0.60 | NPBWR1 (0.50) | NPBWR1MCHR1GABRPGABRDGABRA1 | |
| SCHEMBL16193422 | 0.60 | ALDH1A1 (0.44) | DPP4NPBWR1MCHR1KDM1APHGDH | |
| SCHEMBL16398771 | 0.59 | LTA4H (0.53) | L3MBTL1MEN1ALDH1A1MAPTHPGD | |
| SCHEMBL257565 | 0.59 | RXRA (0.43) | KDM1APHGDHTMPRSS4L3MBTL1ALDH1A1 | |
| SCHEMBL18052567 | 0.59 | DPP4 (0.40) | DPP4KDM1AL3MBTL1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900656-A1 | SPIRO RING COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS | Sunshine Lake Pharma Co., Ltd. (CN) | 2015-08-05 | — | — | EP | disclosed |
| WO-2014019344-A1 | BRIDGED RING COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS AND PHARMACEUTICAL APPLICATIONS THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2014-02-06 | — | — | WO | disclosed |
| EP-2616443-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | Exelixis, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| EP-2509960-A1 | TGR5 AGONISTS | Exelixis, Inc. (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2012037132-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2011071565-A1 | TGR5 AGONISTS | EXELIXIS, INC. (US) | 2011-06-16 | — | — | WO | disclosed |