Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | KCNN3 | Q9UGI6 | 6/20 | 0.34 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.33 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.33 |
| ▸ | CDK9 | P50750 | 7/20 | 0.33 |
| ▸ | CDK4 | P11802 | 3/20 | 0.33 |
| ▸ | CCND1 | P24385 | 3/20 | 0.33 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
| ▸ | CCNH | P51946 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431791 | 0.77 | ALDH1A1 (0.50) | PDE10ACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL30974 | 0.77 | PDE10A (0.67) | PDE10ACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL17026690 | 0.76 | CDK2 (0.48) | PDE10ACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14316241 | 0.73 | CDK2 (0.46) | PDE10ACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL7846977 | 0.72 | PRKAB2 (0.48) | PDE10ACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL26874533 | 0.72 | CCNT1 (0.53) | CCNA2CDK2CCNA1CCNT1CDK9 | |
| SCHEMBL17787567 | 0.71 | CCNT1 (0.43) | PDE10ACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL7847802 | 0.70 | CDK9 (0.52) | PDE10ACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL26868394 | 0.69 | CDK2 (0.46) | PDE10ACHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL7846641 | 0.69 | CHEK1 (0.68) | PDE10ACHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |