Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | PLAUR | Q03405 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | JAK1 | P23458 | 2/20 | 0.51 |
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885351 | 0.84 | ALDH1A1 (0.60) | ALDH1A1PLAURTSHRGAASMN1; SMN2 | |
| SCHEMBL4540201 | 0.81 | MAPT (0.51) | ALDH1A1PLAURTSHRLMNAGAA | |
| SCHEMBL3996738 | 0.81 | TSHR (0.73) | ALDH1A1PLAURTSHRLMNAGAA | |
| SCHEMBL3379273 | 0.79 | ALDH1A1 (0.54) | ALDH1A1TSHRGAASMN1; SMN2HPGD | |
| SCHEMBL944091 | 0.77 | BCAT2 (0.63) | TSHRCYP3A4PDCD1CD274RECQL | |
| SCHEMBL14508043 | 0.76 | HPGD (0.71) | ALDH1A1TSHRHPGDJAK2JAK1 | |
| SCHEMBL3093959 | 0.76 | MAPT (0.55) | ALDH1A1TSHRGAASMN1; SMN2HPGD | |
| SCHEMBL3227656 | 0.75 | MEN1 (0.63) | ALDH1A1TSHRLMNAHPGDRECQL | |
| SCHEMBL5349455 | 0.74 | SMN1; SMN2 (0.67) | ALDH1A1TSHRGAASMN1; SMN2HPGD | |
| SCHEMBL8150805 | 0.74 | HPGD (0.76) | ALDH1A1TSHRLMNASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098892-A1 | BIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000005225-A1 | BIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-02-03 | — | — | WO | disclosed |